Durometry as an outcome measure in juvenile localized scleroderma

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Reliability of using an ultrasound scoring measure for juvenile localized scleroderma (jLS)

Purpose Although ultrasound shows great potential for aiding assessment of LS disease activity, its use has been limited because both image acquisition and interpretation are operator dependent. To facilitate evaluating and to standardize interpretation of jLS ultrasound scans, we generated a scoring measure for evaluating echogenicity and vascularity differences (U-DA, Ped Rheum 2010;8:14). Ob...

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Juvenile localized scleroderma: review of 44 patients

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Localized scleroderma in a cohort of juvenile idiopathic arthritis children

Introduction Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. Localized scleroderma also known as morphea is an inflammatory, fibrosing skin disorder that leads to sclerosis of the dermis and eventually of the underlying tissues. The prevalence is estimated at around 1-9/100,000 with the onset before 10 years of age in 2% of patients. The associatio...

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Long-term methotrexate efficacy in juvenile localized scleroderma

Methods We prospectively followed a cohort of patients with JLS who were enrolled in a double-blind, randomized controlled trial. Oral MTX was used at a dose of 15 mg/m once a week (max 20 mg) for at lest 24 months; prednisone (1 mg/Kg/day, max 50 mg), in a single morning dose for 3 months was added. A target lesion was evaluated clinically, with infrared thermography and using a computerized s...

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Esophageal involvement in juvenile localized scleroderma: a pilot study.

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ژورنال

عنوان ژورنال: British Journal of Dermatology

سال: 2015

ISSN: 0007-0963,1365-2133

DOI: 10.1111/bjd.14103